Engineered CGRP Eye Drops Restore Tear Secretion via TRPM8-SSN Circuitry in a Postrefractive Surgery Mouse Model

Key Points

• This research aims to explore the role of CGRP in tear secretion related to dry eye after refractive surgery.
• Utilized a postrefractive surgery mouse model
• Assessed CGRP expression levels in the cornea
• Examined TRPM8-SSN circuit activity
• CGRP expression decreased in cornea post-surgery
• Lower TRPM8-SSN activity correlated with dry eye symptoms
• eCGRP shows promise as a treatment for preventing and managing dry eye