Study of the Mechanism of Mahuang Lianqiao Chixiaodou Decoction against IgA Nephropathy Based on a Combined Strategy of Transcriptomics and Network Pharmacology Analysis.

Key Points

• This research aims to explore how Mahuang Lianqiao Chixiaodou Decoction (MLCD) affects IgA nephropathy through specific signaling pathways.
• Utilized transcriptomics to identify gene expressions associated with IgA nephropathy
• Applied network pharmacology to analyze the interactions of MLCD components
• Examined effects on the TLR9/MAPK/NF-κB signaling pathway in IgAN models
• MLCD effectively reduces the inflammatory response in IgA nephropathy models
• Significant improvement in kidney function observed
• Regulation of the TLR9/MAPK/NF-κB signaling pathway confirmed as a key mechanism