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CKS-1 and the choreography of meiotic chromosome segregation. | Synapse

January 24, 20260 citations

CKS-1 and the choreography of meiotic chromosome segregation.

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SMShabnam MogharehUniversity of California, Irvine DBDavid BojorquezUniversity of California, Irvine JPJ. Rajan PrabuMax Planck Institute of Biochemistry

Key Points

The research aims to elucidate the role of CKS-1 in the activity of the cyclin B-CDK1 complex during meiosis.
Analyses of meiotic progression
Investigation of cyclin B-CDK1 complex activity
Observation of chromosome segregation during oocyte meiosis
CKS-1 is identified as a critical component of the cyclin B-CDK1 complex
Proper chromosome segregation is dependent on CKS-1 activity
Disruption of CKS-1 function leads to meiotic errors

Abstract

Meiotic progression requires the activity of the cyclin B-CDK1 complex. In this issue, Yang et al. (https://doi.org/10.1083/jcb.202502087) demonstrate that the phospho-adaptor protein CKS-1 functions as a critical component of this complex to ensure proper chromosome segregation during oocyte meiosis.

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Cite This Study

Moghareh et al. (Mon,) studied this question.

synapsesocial.com/papers/697461a8bb9d90c67120b8f5 https://doi.org/https://doi.org/10.1083/jcb.202511196

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