The Protective Effect and Mechanisms of Maxing Kugan Decoction Against Oleic Acid-Induced Acute Lung Injury via Inhibition of Inflammatory Factors, Oxidative Damage, and Modulation of Intestinal Microbiota and Metabolites.

Key Points

• This research aims to investigate how Maxing Kugan Decoction can prevent acute lung injury by inhibiting inflammation and regulating intestinal microbiota.
• In vitro and in vivo experiments to assess the effects of Maxing Kugan Decoction on oleic acid-induced acute lung injury.
• Measurement of inflammatory factors and oxidative damage levels.
• Analysis of intestinal microbiota composition and metabolite profiles.
• Maxing Kugan Decoction significantly reduced inflammation markers in lung tissues.
• The decoction decreased oxidative damage and improved lung function in treated models.
• Regulation of intestinal microbiota balance was observed, indicating a potential mechanism of action.