In this study, we present a new ultra-high-performance surface plasmon resonance (SPR) biosensor with a multilayer design incorporating black phosphorus (BP), zirconium dioxide (ZrO 2 ), and tellurium dioxide (TeO 2 ) nanomaterials to achieve an optimal solution for detecting brain tumors in their early stages in a precise localization manner. Owing to the unique optical properties of BP, ZrO 2 , and TeO 2 , the proposed biosensor has good sensitivity and selectivity with an impressive sensing range of a large refractive index (RI), continuous range, and constant response of both normal and cancerous brain tissues. The performance indices that the proposed biosensor has attained are a high sensitivity of 414.537Formula: see text/RIU, a quality factor (QF) of 177.568 RIUFormula: see text, and a figure of merit (FoM) of 106.148 RIUFormula: see text. This correct resonance behavior and high sensitivity to change in RI validate that the biosensor has high diagnostic potential and accuracy in detecting early-stage brain tumors meticulously and accurately in real time. These values show that the optical performance and the diagnostic accuracy are greatly enhanced compared to traditional SPR biosensors.
Sricharan et al. (Wed,) studied this question.