QQ-OEF mapping demonstrated strong reproducibility across 3 and 1.5 T field strengths, with small mean differences (≤ 1.51%) and strong correlations (r > 0.95).
Observational (n=14)
Does QQ (QSM + qBOLD) OEF mapping demonstrate reproducible brain oxygen extraction fraction measurements across 3 T and 1.5 T MRI field strengths in healthy subjects?
QQ-OEF mapping demonstrates high repeatability and reproducibility for brain oxygen extraction fraction measurements at both 3 T and 1.5 T MRI field strengths.
Effect estimate: mean differences ≤ 1.51%, r > 0.95
ABSTRACT Purpose This study aims to assess the repeatability and reproducibility of qBOLD+QSM (QQ) oxygen extraction fraction (OEF) measurements across 3 and 1.5 T. Methods The effects of field strength on signal to noise ratio (SNR) and OEF sampling time were experimentally assessed in 14 healthy subjects using repeated scans performed at 3 and 1.5 T. Whole‐brain and regional OEF values were analyzed using Bland–Altman and correlation between repeated scans and across field strengths. Results Whole‐brain and regional OEF values showed strong agreement between repeated scans at the same field strength, with minimal differences (≤ 0.74%) and high correlation ( r > 0.92). Across field strengths, comparisons similarly showed small mean differences (≤ 1.51%) and strong correlations ( r > 0.95). Conclusion QQ‐OEF has good repeatability and reproducibility at both 3 and 1.5 T. Good performance at 1.5 T may arise from accurate noise modeling and longer sampling times at lower field strengths.
Zhuang et al. (Fri,) conducted a observational in healthy subjects (n=14). QQ-OEF mapping at 3 T vs. QQ-OEF mapping at 1.5 T was evaluated on Whole-brain and regional OEF values (mean differences ≤ 1.51%, r > 0.95). QQ-OEF mapping demonstrated strong reproducibility across 3 and 1.5 T field strengths, with small mean differences (≤ 1.51%) and strong correlations (r > 0.95).