α-tocopherol alleviates ketamine toxicity in rat brain neurons
Key Points
This research aims to investigate the protective effects of α-tocopherol on ketamine-induced toxicity in rat brain neurons.
Assessed oxidative stress levels in neurons exposed to ketamine
Evaluated membrane integrity through biochemical assays
Measured apoptosis signaling pathways in neuronal cells
α-tocopherol significantly reduced oxidative stress in neurons
It preserved membrane integrity when neurons were treated with ketamine
There was a decrease in apoptosis signaling markers in the presence of α-tocopherol
Abstract
It reduced oxidative stress, preserved membrane integrity, and decreased apoptosis signaling, suggesting its potential antioxidant role in counteracting ketamine neurotoxicity.