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February 5, 2026MedicineOpen Access

Serum 25-hydroxyvitamin D as a dynamic biomarker for preeclampsia risk across pregnancy trimesters: A retrospective case–control study

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Authors

FHFeijun HuSDShunlan DuHLHuaqing Li

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Overview

Retrospective case–control study evaluates serum 25(OH)D levels and preeclampsia risk in pregnant women, suggesting early screening improvements.

Key Points

  • Evaluate the association between serum 25-hydroxyvitamin D levels and preeclampsia risk during pregnancy.
  • Retrospective case–control design with 301 pregnant women
  • Measured serum 25(OH)D levels in early, mid, and late pregnancy
  • Analyzed correlations and conducted logistic regression for risk assessment
  • Significant inverse relationship between 25(OH)D levels and blood pressure/proteinuria, especially in late pregnancy
  • Decreased 25(OH)D levels significantly associated with increased preeclampsia risk, adjusted odds ratio = 0.790
  • Highest predictive accuracy for preeclampsia in early pregnancy with AUC = 0.969

Cite This Study

Hu et al. (2026) studied this question.

synapsesocial.com/papers/69843383f1d9ada3c1fb0b52https://doi.org/10.1097/md.0000000000047364
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