Aggravation and ongoing insulin resistance increased ischemic heart disease risk by ~49% and 47%, respectively, compared to normal status over 8 years.
Does the change in insulin resistance status over time affect the risk of developing ischemic heart disease?
Aggravation or ongoing presence of insulin resistance over time is associated with a significantly higher risk of developing ischemic heart disease compared to maintaining normal insulin sensitivity.
Absolute Event Rate: 0% vs 0%
Abstract Introduction Insulin resistance is a known risk factor for cardiovascular disease. However, there is a paucity of reports on long-term follow-up of whether changes in insulin resistance status affect the risk of ischemic heart disease (IHD). Purpose This study analyzed the occurrence of IHD related to changes in insulin resistance status. Methods Data of population-based cohort were obtained from the Korea National Health institute of health during January 2001 to December 2020. Among 10,030 participants were enrolled. We included 7,739 participants. Changes in MetS status were categorized into four levels: aggravation, stable, ongoing insulin resistance and improvement over six-years of change. Results During a 6 years of index time periods, there were changes in insulin resistance status, with 21.4% showing aggravation, 40.3% ongoing insulin resistance, 31.7% showing no development of insulin resistance and 10.8% showing improvement of insulin resistance status. During about 8-year follow up period, incidence of IHD was presented with 260 participants. When adjusted for gender, age, diabetes, hypertension, body mass index, economic status, history of myocardial infarction, heart failure, and stroke, the HR and 95% CI for the occurrence of IHD in the aggravation of stable insulin resistance group compared to the normal status group were 1.49 (1.09 to 2.04), P=0.013. For the ongoing of insulin resistance group, the HR and 95% CI were 1.47 (1.02 to 2.12), P =0.041. For the improvement of the insulin resistance group, the HR and 95% CI were 1.15 (0.69 to 1.90), P =0.595. Conclusions During the follow-up period, the ongoing and aggrevate insulin resistance group reported a higher incidence of IHD compared with normal group. Further detailed analysis and confirmation of results for other cardiovascular diseases may also be necessary.Kaplan-Meier curve of Ischemic disease hazard ratio of Ischemic disease
Ra et al. (Sat,) reported a other. Aggravation and ongoing insulin resistance increased ischemic heart disease risk by ~49% and 47%, respectively, compared to normal status over 8 years.