A general method for the direct trifluoromethylation and chlorodifluoromethylation of Reformatsky reagents derived from various amides or ketones using YlideFluor or YlideFluor-CF2Cl was described. This reaction proceeds under mild conditions and exhibits a broad functional group tolerance. The utility of this protocol was demonstrated through the synthesis of trifluoromethylated derivatives of two pharmaceutical agents, donepezil and ibudilast.
Wan et al. (Thu,) studied this question.