Abstract Background Amyloidosis affecting the aorta is an emerging concern, with deposits causing stiffening, aneurysms, and dissections. Traditionally linked to aging, recent findings suggest aortic amyloidosis may be a distinct entity, though its prevalence remains unclear. Purpose This study uses National Inpatient Sample (NIS) data to investigate the prevalence and cardiovascular outcomes of amyloidosis in aortic disease (AD). Methods A retrospective study used the NIS (October 2015 - December 2021) to identify patients with AD and amyloidosis using ICD-10 codes. Descriptive statistics compared baseline characteristics, with chi-square tests for categorical variables and t-tests or Mann-Whitney U tests for continuous data. Statistical significance was set at p 0.05. Cell sizes ≤10 were suppressed for confidentiality. Results Concomitant AD and amyloidosis were found in 2,735 of 1,673,284 patients (0.2 %; Table 1). Light chain (AL) amyloidosis was more common (77.1%) and patients were significantly younger (p = 0.009) than those with transthyretin amyloidosis (ATTR, 22.9%). Amyloidosis patients were overall older (76.48 ± 10.08), had more thoracic aneurysms (43.7%), higher rates of heart failure (54.4%) and in-hospital mortality (7.7%) compared to non-amyloidosis patients (p0.001). Conclusions Amyloidosis and AD rarely coincide and cannot be conclusively linked. However, the occurrence may be underrecognized. Further research is needed to clarify amyloidosis’ role in aortic disease.Aortic Disease and Cardiac Amyloidosis Patient History
Ersoezlue et al. (Sat,) studied this question.