The reaction of bromoacetylmetronidazole with monoterpene thiols of pinane and bornane structures yielded new sulfides, which were tested for antimicrobial activity and cytotoxicity. Compounds with fragments of myrtane and myrtentiols showed fungicidal activity against yeast fungi Candida albicans, Candida tropicalis and Candida parapsilosis, while derivatives with fragments of hydroxypinane thiols were not toxic to cells of the lung epithelium of the cow embryo.
S.N. Subbotina (Wed,) studied this question.