The aim is to evaluate the protective effects of taurochenodeoxycholic acid (TCDCA) on corneal endothelial cells in Fuchs' endothelial corneal dystrophy (FECD).
In vitro experiments on corneal endothelial cells
Exposure to TCDCA
Assessment of calcium signaling pathways
TCDCA effectively protects corneal endothelial cells from damage
Activation of calcium signaling was observed
TCDCA may slow the progression of FECD
Abstract
TCDCA demonstrated a protective effect on corneal endothelial cells during the pathogenesis of FECD. Therefore, TCDCA may be a promising novel therapeutic target for attenuating the progression of FECD.