What does this research mean for the field?

In overweight and obese patients undergoing PCI, elevated hsCRP is associated with a 19% higher risk of major adverse cardiovascular and cerebrovascular events (MACCEs), while no association is found in normal BMI patients. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

What question did this study set out to answer?

This study aims to determine how elevated hsCRP affects clinical outcomes in patients undergoing PCI based on their BMI classifications.

February 8, 2026

High-sensitivity C-Reactive protein predicts post-percutaneous coronary intervention cardiovascular risk with bmi threshold effect: evidence from a prospective registry study

Key Result

Elevated hsCRP (≥2 mg/L) predicts higher MACCE risk with adjusted HR 1.19 in overweight and obese PCI patients, but not in normal BMI individuals.

Key Points

This study aims to determine how elevated hsCRP affects clinical outcomes in patients undergoing PCI based on their BMI classifications.
Included 19,027 patients undergoing PCI categorized into normal, overweight, and obese BMI groups.
Defined elevated hsCRP as ≥2 mg/L.
Evaluated primary endpoints as major adverse cardiovascular and cerebrovascular events (MACCEs).
Elevated hsCRP rates were 26.7%, 31.1%, and 39.7% across normal, overweight, and obese groups, respectively.
MACCE rates were significantly higher for patients with elevated hsCRP in overweight (11.1%) and obese (11.5%) groups compared to their respective normals.
After adjustments, elevated hsCRP was significantly associated with MACCEs in overweight (adj.HR = 1.19) and obese (adj.HR = 1.19) groups, but not in normal group.

Structured PICO

Does elevated hsCRP predict major adverse cardiovascular and cerebrovascular events in patients undergoing PCI across different BMI categories?

Population

19,027 patients who underwent percutaneous coronary intervention (PCI) at a large tertiary care center, categorized into three BMI groups: normal (8.5 to < 24 kg/m2, n=5,017), overweight (24 to < 28 kg/m2, n=9,515), and obese (≥ 28 kg/m2, n=4,495).

Intervention

Elevated high-sensitivity C-reactive protein (hsCRP ≥2 mg/L)

Comparator

Non-elevated high-sensitivity C-reactive protein (hsCRP <2 mg/L)

Outcome

Major adverse cardiovascular and cerebrovascular events (MACCEs), including all-cause mortality, myocardial infarction, stroke, and revascularizationcomposite

Elevated hsCRP predicts worse cardiovascular outcomes post-PCI specifically in overweight and obese patients, but not in those with normal BMI.

Main Result

Absolute Event Rate: 0% vs 0%

Abstract

Abstract Background High-sensitivity C-reactive protein (hsCRP) is a key prognostic factor in patients undergoing percutaneous coronary intervention (PCI). However, the impact of body mass index (BMI) on its prognostic value is debated. Purpose This study examines the association between elevated hsCRP and clinical outcomes in PCI patients according to BMI. Patients and Methods 19,027 patients who underwent PCI at a large tertiary care center were included and categorized into three BMI groups: normal (8.5 to 24 kg/m2, n=5,017), overweight (24 to 28 kg/m2, n =9,515), obese (≥ 28 kg/m2, n =4,495). Elevated hsCRP was defined as ≥2 mg/L. The primary endpoint was major adverse cardiovascular and cerebrovascular events (MACCEs), including all-cause mortality, myocardial infarction, stroke, and revascularization. Results Elevated hsCRP was found in 26.7%, 31.1%, and 39.7% of the normal, overweight, and obese groups, respectively (p 0.001). MACCEs rates were higher in patients with elevated hsCRP in both overweight (9.1% vs. 11.1%) and obese (9.7% vs. 11.5%) groups. After multivariate adjustment, elevated hsCRP was significantly associated with MACCEs in overweight adj.HR = 1.19, 95% CI (1.04-1.36), p = 0.014 and obese adj.HR = 1.19, 95% CI (1.01-1.43), p = 0.043, but not in the normal group adj.HR = 1.04, 95% CI (0.85-1.27) , p = 0.690. Conclusion Elevated hsCRP is more prevalent in higher BMI groups and predicts worse outcomes in overweight and obese PCI patients.

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Cite This Study

Chen et al. (Sat,) reported a other. Elevated hsCRP (≥2 mg/L) predicts higher MACCE risk with adjusted HR 1.19 in overweight and obese PCI patients, but not in normal BMI individuals.

synapsesocial.com/papers/698829520fc35cd7a8849939 https://doi.org/https://doi.org/10.1093/eurheartj/ehaf784.3779

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