Cysteine-selective¹88Re]Re (v) radiolabelling of a Nanobody® for targeted radionuclide therapy using a “chelate-then-click” approach

Key Points

• The aim is to explore the use of rhenium-188 for effectively radiolabelling an anti-c-Met Nanobody using click chemistry.
• Utilized bioorthogonal click chemistry for radiolabelling.
• Employed rhenium-188 in conjunction with a Nanobody®.
• Applied a 'chelate-then-click' methodology for labeling.
• Successfully radiolabelled the anti-c-Met Nanobody with rhenium-188.
• Demonstrated the potential for targeted radionuclide therapy using this approach.