What question did this study set out to answer?

The trial aims to compare very restrictive and standard strategies for red blood cell transfusion in critically ill patients with anemia.

February 9, 2026Open Access

Very restrictive versus standard RBC transfusion strategy in anemic critically ill patients (VeRTEx): Protocol for a pilot randomized controlled trial

Key Points

The trial aims to compare very restrictive and standard strategies for red blood cell transfusion in critically ill patients with anemia.
Pilot randomized controlled trial design
Involving anemic critically ill patients
Comparison of two transfusion strategies
Registration with SPIRIT guidelines
Evaluation of feasibility for larger trials
Assessment of safety and efficacy of transfusion strategies

Abstract

This trial was registered at Highly restrictive vs normal red blood cell transfusion strategy in anemic critically ill patients - A feasibility trial | Research with human participants (identifier: NL-OMON57318) at 12th of February 2025. Note: the numbers in brackets in this protocol refer to the SPIRIT(1) checklist item numbers.

Very restrictive versus standard RBC transfusion strategy in anemic critically ill patients (VeRTEx): Protocol for a pilot randomized controlled trial

Key Points

Abstract

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