Cystathionine quantification by 1H-MRS reflects biologically meaningful metabolic differences among adult-type diffuse gliomas, with higher levels characteristic of oligodendrogliomas compared with astrocytomas. However, overlap with glioblastomas limits its role as a stand-alone discriminator. When interpreted alongside 2HG and conventional imaging features, cystathionine may serve as a supportive metabolic marker to enhance preoperative glioma subtype classification.
Kikuchi et al. (Fri,) studied this question.
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