Single cell study of bladder cancer chemotherapy (PDX scRNA data) | Synapse
February 11, 2026Open Access
Single cell study of bladder cancer chemotherapy (PDX scRNA data)
Key Points
This research aims to explore how lipid oxidation in cancer-associated fibroblasts affects CD8+ T-cell activity and treatment responses in bladder cancer.
Analyzed single-cell RNA sequencing (scRNA) data from patient-derived xenografts (PDX)
Evaluated the interactions between cancer-associated fibroblasts and CD8+ T-cells
Assessed therapeutic responses based on lipid oxidation levels
Lipid oxidation reprogramming in fibroblasts significantly enhanced CD8+ T-cell cytotoxicity
Improved therapeutic responses were observed in models treated with chemotherapy
The findings support the potential of targeting lipid metabolism in enhancing cancer immunotherapy
Abstract
Lipid Oxidation Reprogramming in Cancer-Associated Fibroblasts Enhances CD8+ T-Cell Cytotoxicity and Therapeutic Response (PDX scRNA data)