What question did this study set out to answer?

This research aims to evaluate the preventive effects of powder bergamot juice on kidney disease processes induced by a Western diet.

February 12, 2026Open Access

Preventive Effect of Powder Bergamot Juice (C itrus bergamia Risso & Poiteau) on Pathophysiological Processes of Renal Disease in an Experimental Western Diet Model

Key Points

This research aims to evaluate the preventive effects of powder bergamot juice on kidney disease processes induced by a Western diet.
Male Wistar rats were divided into four groups: control diet, control + PBJ, Western diet, and Western diet + PBJ.
PBJ was administered at a dosage of 250 mg/kg for 20 weeks.
The Western diet included a 25% sucrose solution in drinking water and rich in sugars and fats.
Measurements included nutritional, metabolic, hormonal, renal, and oxidative stress markers.
Statistical analyses were conducted using two-way ANOVA/Tukey's post-hoc and Kruskal–Wallis/Dunn's post-hoc methods.
The Western diet increased caloric intake, body weight, adiposity index, glucose, triglycerides, and renal oxidative stress markers.
PBJ supplementation reduced adiposity and triglycerides, and improved antioxidant enzyme activity.
PBJ preserved kidney function and attenuated metabolic and oxidative alterations caused by the Western diet.

Abstract

ABSTRACT The Western diet (WD), rich in sugars and saturated fats, is linked to metabolic disturbances that contribute to chronic kidney disease (CKD). Natural antioxidants have been investigated in several diseases, including bergamot ( Citrus bergamia ), a citrus fruit rich in polyphenols with recognized antioxidant and anti‐inflammatory properties. This study evaluated the preventive effect of powder bergamot juice (PBJ) on renal alterations induced by WD in male Wistar rats. Animals were allocated into four groups ( n = 7): control diet, control + PBJ (250 mg/kg), WD; and WD + PBJ for 20 weeks. WD groups also received 25% sucrose in drinking water. Nutritional, metabolic, hormonal, renal, and oxidative stress (OS) markers were measured. Statistical analyses included two‐way ANOVA/Tukey's post‐hoc and Kruskal–Wallis/Dunn's post‐hoc ( p < 0.05). WD increased caloric intake, body weight, adiposity index, glucose, triglycerides, and renal OS markers, and reduced kidney function. PBJ supplementation reduced adiposity and triglycerides, improved antioxidant enzyme activity, and preserved renal function. PBJ attenuated metabolic and oxidative alterations induced by WD, supporting its potential as a preventive strategy against early renal dysfunction associated with CKD.

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Cite This Study

Santos et al. (Sun,) studied this question.

synapsesocial.com/papers/698d6e925be6419ac0d545c0 https://doi.org/https://doi.org/10.1002/mnfr.70411

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