Synthesis of isoxazoles and their hydrazinolysis to 5-aminopyrazoles: an approach to fluorescent derivatives

Key Points

• The aim is to synthesize 5-amino-3-(hetero)arylpyrazoles from 5-(hetero)aryl-isoxazoles while exploring their fluorescent properties.
• TFA-mediated microwave-assisted synthesis
• Used 5-(hetero)aryl-isoxazoles as substrates
• Conducted under eco-friendly conditions
• Studied the photophysics of fluorescent derivatives
• Successfully synthesized 5-amino-3-(hetero)arylpyrazoles
• Demonstrated eco-friendly synthesis efficiency
• Identified photophysical properties of synthesized fluorescent derivatives