What question did this study set out to answer?

This research aims to explore the enantioselective synthesis of gamma-butenolides derived from Streptomyces rochei.

February 12, 2026Organic & Biomolecular Chemistry0 citations

Enantioselective Synthesis of Antibiotic Inducing Gamma-Butenolides from Streptomyces rochei and Derivatives

HHHaylie E HenniganPurdue University West Lafayette MFManuela Frias-GomezPurdue University West Lafayette KCKylie G CastatorPurdue University West Lafayette

Key Points

This research aims to explore the enantioselective synthesis of gamma-butenolides derived from Streptomyces rochei.
Utilized a divergent synthesis approach
Investigated regulatory systems in antibiotic production
Analyzed derivatives of gamma-butenolides
Successfully synthesized two known gamma-butenolides
Demonstrated enantioselectivity in synthesis process
Identified potential pathways for antibiotic production

Abstract

Given the challenges of discovering new natural products, further investigations into the regulatory systems that control their production are needed. Herein, we describe an enantioselective, divergent synthesis of two known...

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