Neonatal HPeV meningitis after the COVID-19 pandemic presented with prolonged fever (mean 4.3 days) and 50% of patients required high-flow nasal cannula support for respiratory symptoms.
Observational (n=8)
No
Neonatal HPeV meningitis after the COVID-19 pandemic may present with prolonged fever, increased need for respiratory support, and hyponatremia without typical symptoms like rash or seizures.
Purpose Human parechovirus (HPeV) is one of the major causes of viral meningitis in neonates. Following the COVID‐19 pandemic, a resurgence of HPeV infections was reported worldwide. This exploratory case series is aimed at describing the symptoms of neonatal HPeV meningitis occurring after the lifting of large‐scale quarantine measures. Methods We retrospectively reviewed eight neonates admitted between June 1, 2023, and September 30, 2023, with fever and HPeV detected in cerebrospinal fluid (CSF) using the FilmArray Meningitis/Encephalitis Panel. Demographic variables, clinical presentation, laboratory data, respiratory support requirements, and treatment courses were analyzed. Results Fever was the primary presenting symptom. Despite the absence of leukocytosis or pleocytosis, fever duration was prolonged (mean 4.3 days). Four patients (50%) exhibited respiratory symptoms requiring high‐flow nasal cannula support. Hyponatremia occurred in two neonates without neurological manifestations—an observation not commonly described in previous cohorts. No patients required invasive ventilation. Conclusion This small, single‐center series suggests possible variations in neonatal HPeV presentation after the COVID‐19 pandemic; however, findings are preliminary and hypothesis‐generating. Larger multicenter studies with subtype analysis and long‐term neurodevelopmental follow‐up are essential.
Kim et al. (Thu,) conducted a observational in Human parechovirus (HPeV)-related meningitis (n=8). Neonatal HPeV meningitis after the COVID-19 pandemic presented with prolonged fever (mean 4.3 days) and 50% of patients required high-flow nasal cannula support for respiratory symptoms.