The association between single-nucleotide polymorphisms of FDPS Rs2297480 and MECP2 Rs2734647 genes and the susceptibility to rheumatoid arthritis in Egyptian patients

Key Points

• The research aims to explore how specific genetic variations in FDPS and MECP2 relate to rheumatoid arthritis risk in Egyptian patients.
• Analyzed genotypes of FDPS (rs2297480) and MECP2 (rs2734647) genes in patients with rheumatoid arthritis.
• Compared genotypes between those with and without rheumatoid arthritis to identify associations.
• The FDPS (rs2297480) TT genotype appeared to offer protection against rheumatoid arthritis.
• The MECP2 (rs2734647) TT genotype was associated with an increased risk of rheumatoid arthritis, while the CC genotype seemed protective.