LncRNA RNF144A-AS1 increases P300-mediated H4K5 acetylation of PDE4 to promote keloid fibrosis

Key Points

• The aim is to investigate how RNF144A-AS1 contributes to keloid fibrosis through its interaction with P300 and PDE4.
• Identified the role of lncRNA RNF144A-AS1 in keloid fibrosis.
• Measured P300-mediated H4K5 acetylation levels.
• Analyzed the interaction between RNF144A-AS1 and PDE4.
• RNF144A-AS1 enhances P300 activity.
• Increased H4K5 acetylation of PDE4 is observed.
• Keloid fibrosis is promoted through this mechanism.