Personalized health education integrating digital technologies reduced 3-month weight by 3.08 kg vs. 0.67 kg in controls and identified 3-month weight reduction as protective (OR 0.64) while elevated LDL-C increased CVD risk (OR 1.38) in offspring of CHD patients.
Observational (n=88)
Yes
What are the independent short-term cardiovascular risk factors in the offspring of patients with early-onset coronary heart disease?
Short-term changes in weight, waist circumference, and LDL-C are independent cardiovascular risk factors in the offspring of patients with early-onset coronary heart disease, highlighting targets for early digital health interventions.
Effect estimate: 3-month weight change OR 0.64 (95% CI 0.53-0.76), P=0.002; 3-month waist circumference change OR 0.68 (95% CI 0.58-0.79), P=0.005; 3-month LDL-C level OR 1.38 (95% CI 1.18-1.60), P=0.0007; 3-month total cholesterol level OR 0.88 (95% CI 0.79-0.98), P=0.028 (95% CI See OR 95% CI values above)
Absolute Event Rate: -3.08% vs -0.67%
p-value: p=All significant indicators P<0.05
This study clarified the key short-term independent cardiovascular risk factors in the offspring of CHD patients. The constructed personalized health pathway focused on weight/waist circumference control and blood lipid regulation, integrating diet, exercise, medication, psychological support, and digital health technologies. It provided a feasible and targeted intervention framework for the early prevention of CVD in this high-risk population, addressing the limitations of generalized interventions in existing studies.
Li et al. (Sat,) conducted a observational in Offspring aged 30-65 years of patients with early-onset coronary heart disease (CHD) without definite cardiovascular disease history (n=88). Personalized health education pathway integrating diet, exercise, medication, psychological support, and digital health technologies vs. Control: Offspring of parents suspected of CHD but excluded by angiography, receiving usual care was evaluated on Change in short-term cardiovascular risk factors (weight change, waist circumference change, LDL-C level, total cholesterol level) associated with cardiovascular disease risk (3-month weight change OR 0.64 (95% CI 0.53-0.76), P=0.002; 3-month waist circumference change OR 0.68 (95% CI 0.58-0.79), P=0.005; 3-month LDL-C level OR 1.38 (95% CI 1.18-1.60), P=0.0007; 3-month total cholesterol level OR 0.88 (95% CI 0.79-0.98), P=0.028, 95% CI See OR 95% CI values above, p=All significant indicators P<0.05). Personalized health education integrating digital technologies reduced 3-month weight by 3.08 kg vs. 0.67 kg in controls and identified 3-month weight reduction as protective (OR 0.64) while elevated LDL-C increased CVD risk (OR 1.38) in offspring of CHD patients.