What question did this study set out to answer?

The aim is to evaluate the efficacy of a CBD/HA suppository combination in relieving symptoms of abacterial prostatitis.

February 21, 2026Open Access

Cannabidiol-hyaluronic acid combination delivered rectally for attenuating abacterial prostatitis symptoms: Single-arm open-label pilot clinical trial

Key Points

The aim is to evaluate the efficacy of a CBD/HA suppository combination in relieving symptoms of abacterial prostatitis.
Single-arm open-label pilot clinical trial design.
Participants administered CBD/HA suppositories rectally.
Assessment of symptom relief using NIH-CPSI, IPSS, and IIEF-5 scales.
Participants reported potential symptom relief from abacterial prostatitis.
A favorable tolerability profile was observed.
Nuanced analysis indicated clinically meaningful benefits in symptom scores for most participants.

Abstract

The administration of the suppositories with CBD/HA action demonstrated potential symptom relief in CP/CPPS with a favourable tolerability profile. A more nuanced analysis of NIH-CPSI changes and IPSS and IIEF-5 data suggests a clinically meaningful benefit for most participants.

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