What question did this study set out to answer?

The study aims to validate a next-generation sequencing-based RNA fusion panel for detecting gene fusions in haematological malignancies.

February 22, 2026

Validation of a next-generation sequencing-based RNA fusion panel for haematological malignancies in a tertiary care hospital

Key Points

The study aims to validate a next-generation sequencing-based RNA fusion panel for detecting gene fusions in haematological malignancies.
Validation of RNA fusion panel
Utilization of next-generation sequencing technology
Assessment of diagnostic accuracy in a tertiary care hospital
Comparison with existing methods
The RNA fusion panel effectively detects gene fusions in haematological malignancies
Improved diagnostic capabilities over traditional methods like cytogenetics and FISH
Potentially enhances treatment decisions and prognostic evaluations

Abstract

Introduction: Gene fusions are the key drivers in haematological malignancies, informing diagnosis, prognosis, and therapeutics. Their growing inclusion in the World Health Organization classification highlights the clinical importance of detecting fusions in routine diagnostics. Current testing methods (cytogenetics/FISH) are limited by their targeted design and inability to detect cryptic or novel rearrangements.

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