14-Peptide and 9-Protein Signature predicts the development of clinical perineural spread in primary cutaneous head and neck squamous cell carcinoma | Synapse
February 22, 2026
14-Peptide and 9-Protein Signature predicts the development of clinical perineural spread in primary cutaneous head and neck squamous cell carcinoma
Key Points
The aim is to create a proteomic signature to anticipate perineural spread in skin cancers.
Analyzed peptide and protein profiles
Developed a predictive model for clinical outcomes
Focused on primary cutaneous head and neck cancers
Identified a specific 14-peptide and 9-protein biomarker signature
Prediction of perineural spread was improved
Potentially useful for clinical decision-making
Abstract
Study objective: Construction of a proteomic signature to predict the development of perineural spread (PNS) in primary cutaneous head and neck squamous cell carcinoma (SCC).