Analgesic and Antidiarrheal Properties of Lappaconitine, Possibly Through Cyclooxygenase and µ‐Opioid Receptor Interaction Pathways: In Vivo and In Silico Studies

Key Points

• The research aims to investigate the analgesic and antidiarrheal effects of lappaconitine and its interaction with cyclooxygenase and mu-opioid receptors.
• Conducted in vivo studies to assess pain relief and diarrhea reduction effects of lappaconitine.
• Performed in silico analyses to explore molecular interactions with cyclooxygenase and mu-opioid receptors.
• Examined synergistic effects with diclofenac sodium and loperamide.
• Lappaconitine showed significant analgesic properties in tested models.
• It effectively reduced diarrhea symptoms.
• Synergistic interactions with diclofenac sodium and loperamide were observed, enhancing overall efficacy.