Targeting cancer stem cells predicts response and reverses chemoresistance in ascites-derived ovarian cancer organoids

Key Points

• The aim is to understand how targeting cancer stem cells can predict treatment response and overcome chemoresistance in ovarian cancer.
• Investigation of ascites-derived ovarian cancer organoids
• Combination treatment of OH2 and cisplatin
• Assessment of drug response and chemoresistance
• Targeting cancer stem cells predicts response to treatment
• Combination of OH2 and cisplatin effectively reverses chemoresistance
• Ascites-derived organoids provide a reliable platform for individualized drug testing