What does this research mean for the field?

Apathy is a prevalent and clinically relevant feature in Major Depressive Disorder (MDD), associated with greater psychopathology and poorer quality of life. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.CHALLENGES_CONSENSUS.

What question did this study set out to answer?

This research aims to explore the prevalence and impact of apathy in individuals with Major Depressive Disorder (MDD).

February 26, 2026Open Access

Depression and apathy: examining an overlooked dimension

Key Points

This research aims to explore the prevalence and impact of apathy in individuals with Major Depressive Disorder (MDD).
Assessed 154 outpatients with MDD using various scales including AES-C and BDI-II during clinical stability phase.
Categorized patients based on apathy presence using AES-C score.
Conducted group comparisons and stepwise logistic regression to identify predictors and clinical differences.
Apathy was identified in 48% of the sample.
Patients with apathy exhibited higher depression scale scores and lower cognitive performance.
Significant differences were found in initiation and executive functioning related to apathy.

Abstract

Apathy is a significant yet frequently overlooked aspect of Major Depressive Disorder (MDD), often confused with anhedonia, and with the potential to influence clinical outcomes and quality of life regardless of the severity of depressive symptoms. Despite its importance, the relationship between apathy and depression remains underrepresented in current research. This study aims to assess the prevalence of apathy in a sample of outpatients affected by MDD and to explore its clinical, cognitive, and functional correlates. Outpatients with MDD (n = 154) during a clinical stability phase have been assessed using the Apathy Evaluation Scale-Clinician version (AES-C), Dimensional Apathy Scale (I-DAS), MADRS, BDI-II, MMSE, PANSS, EQ-5D-3 L, and CGI-S. Patients were categorized into two groups according to the presence/absence of apathy (AES-C score ≥ 42). Groups comparison and a stepwise logistic regression were run to identify clinical differences between groups and the predictors of apathy. Apathy was detected in 48% of the sample. Patients with apathy scored higher on depression scales, had lower cognitive performance, more negative and general psychopathology, greater clinical severity, and reduced quality of life. Significant differences emerged in initiation and executive apathy. Logistic regression identified MADRS item 8 “inability to feel” and BDI-II item 12 “loss of interest” as the factors showing the strongest association with apathy. Apathy is a prevalent and clinically relevant feature in MDD, associated with greater psychopathology and functional impairment. Findings support the need to routinely assess apathy in clinical setting, even during symptomatic stability phases. Specific symptoms may serve as key markers for its identification. Apathy is a prevalent and clinically relevant feature in major depressive disorder (MDD). Patients with apathy reported greater clinical severity and poorer quality of life. “Inability to feel” and “loss of interest” are the strongest predictors of apathy in MDD. Apathy in MDD might be a bridging dimension between anhedonia and cognitive symptoms.

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Cite This Study

Carbone et al. (Tue,) studied this question.

synapsesocial.com/papers/699fe37b95ddcd3a253e756b https://doi.org/https://doi.org/10.1186/s12991-026-00641-w

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