PD-1 inhibitors combined with induction chemotherapy followed by chemoradiotherapy in HPV-negative locally advanced head and neck squamous cell carcinoma: a real-world study | Synapse
February 27, 2026Open Access
PD-1 inhibitors combined with induction chemotherapy followed by chemoradiotherapy in HPV-negative locally advanced head and neck squamous cell carcinoma: a real-world study
Key Points
The research aims to evaluate the effectiveness of PD-1 inhibitors when used with induction chemotherapy and chemoradiotherapy in HPV-negative locally advanced head and neck cancer.
Analyzed treatment outcomes in patients receiving PD-1 inhibitors with induction chemotherapy.
Monitored tolerability of treatment-related adverse events (TRAEs).
Utilized real-world data from clinical practice settings.
Significant improvement in treatment outcomes with the addition of PD-1 inhibitors.
TRAEs were found to be tolerable among the patient cohort.
Overall survival and progression-free survival rates increased compared to standard treatment alone.
Abstract
The addition of PD-1 inhibitors to IC significantly improves outcomes with tolerable TRAEs in patients with HPV-negative LA-HNSCC.