Myeloid KIF13B suppresses the STT3A/CTSD/THBS1 Axis to prevent MASH

Key Points

• The research aims to define the regulatory mechanisms involved in macrophage-hepatocyte interactions during MASLD.
• Identified the ZNF384/KIF13B/STT3A/CTSD/THBS1 axis in macrophages and hepatocytes.
• Examined the role of KIF13B in the regulation of this axis.
• Investigated the implications for MASLD progression.
• Establishment of a new regulatory pathway essential for MASLD.
• KIF13B suppression linked to dysregulation of the STT3A/CTSD/THBS1 axis.
• Potential therapeutic targets were identified for MASLD management.