A Combined Microwave/Continuous Flow Approach for the Iodination of Anilines and Consecutive Mizoroki-Heck Cross-Coupling

Key Points

• To develop a microwave-assisted continuous-flow method for efficient iodination of anilines while controlling regioselectivity.
• Utilized microwave-assisted techniques for iodination of unprotected anilines.
• Applied continuous-flow methodology to enhance reaction efficiency.
• Controlled regioselectivity and over-halogenation during the iodination process.
• Achieved selective iodination of anilines without the need for protecting groups.
• Maintained control over regioselectivity in the iodination process.
• Facilitated consecutive Mizoroki-Heck cross-coupling reactions with high efficiency.