A Case of Advanced Squamous Cell Carcinoma of the Lung with Hypercalcemia as a Sign of Cytokine Release Syndrome Induced by Combination Therapy with Nivolumab and Ipilimumab

Key Points

• To investigate the relationship between hypercalcemia and cytokine release syndrome in advanced lung cancer treatment with nivolumab and ipilimumab.
• Case report detailing a 76-year-old male with stage IVB lung squamous cell carcinoma.
• Combination therapy with nivolumab and ipilimumab was initiated.
• Monitoring for signs of hypercalcemia and cytokine release syndrome during treatment.
• Patient developed hypercalcemia and associated symptoms during treatment.
• Initial hydration did not improve calcium levels, but denosumab reduced calcium afterwards.
• Cytokine release syndrome was diagnosed based on emerging symptoms, leading to corticosteroid treatment.