Question It remains unclear whether deep learning-based synthetic 3D-T1w images from various inputs preserve regional atrophy patterns sufficiently to serve as input for automated volumetry. Findings Deep learning-based synthetic T1w images overestimate regional and global brain volumes in neurodegenerative diseases and controls, increasing with lower quality inputs. Clinical relevance Deep learning-based synthetic images should only be used with caution for volumetric evaluation of brain MRI scans. If possible, 3D scans should be used as input.
Riedel et al. (Fri,) studied this question.