Dysregulated Klotho and FGF23 signaling aggravates vascular remodeling in age-related pulmonary hypertension.

Key Points

• The research aims to explore the role of Klotho and FGF23 signaling in pulmonary vascular remodeling associated with age-related pulmonary hypertension.
• Examined mechanisms of pulmonary vascular remodeling in pulmonary arterial hypertension (PAH).
• Identified the role of FGF23 accumulation in vascular changes.
• Evaluated Klotho/FGF23 signaling as a therapeutic target.
• FGF23 accumulation contributes to pulmonary vascular remodeling.
• Dysregulated Klotho/FGF23 signaling worsens pulmonary hypertension.
• Targeting this pathway may offer a new treatment for elderly patients.