What question did this study set out to answer?

To assess the prognostic value of white cell-to-lymphocyte ratio (WLR) for predicting overall survival in glioma patients.

March 1, 2026Open Access

Prognostic Superiority of the White Cell-to-Lymphocyte Ratio (WLR) in Predicting Overall Survival in Patients With Gliomas

Key Points

To assess the prognostic value of white cell-to-lymphocyte ratio (WLR) for predicting overall survival in glioma patients.
Retrospective analysis of glioma patients from the INSCOC database
Random split of patients into training and validation cohorts (7:3)
Utilized Kaplan–Meier analysis and Cox regression to evaluate survival associations
Developed and validated a WLR-based nomogram for survival prediction
Optimal WLR cutoff identified at 4.182
Patients with WLR ≥4.182 had significantly worse overall survival (p<0.01)
Positive dose–response relationship between WLR and mortality risk observed
Age, smoking, drinking, and WLR group were independent predictors of overall survival (all p<0.05)
Nomogram demonstrated good prediction ability for 1-, 3-, and 5-year overall survival

Abstract

Background/Aim: Systemic inflammation influences glioma progression. We evaluated the prognostic value of the white cell-to-lymphocyte ratio (WLR) and aiming to develop a practical survival prediction model. Patients and Methods: Patients with glioma from the INSCOC database were retrospectively analyzed and randomly split into training and validation cohorts (7:3). Kaplan–Meier analysis, restricted cubic splines, and Cox regression assessed associations between WLR and overall survival (OS). A WLR-based nomogram was established and internally validated using calibration and decision curve analysis. Results: The optimal WLR cutoff was 4.182. Patients with WLR ≥4.182 had significantly worse OS (ppConclusion: WLR is an independent, readily available prognostic marker in glioma. A WLR-based nomogram may aid individualized risk stratification and clinical decision-making.

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