Fruquintinib potentiates the radiosensitivity of colorectal cancer by exacerbating DNA damage

Key Points

• This research examines how fruquintinib enhances the effectiveness of radiotherapy in colorectal cancer by affecting DNA damage repair mechanisms.
• Investigated the effects of fruquintinib on tumor cells during radiotherapy.
• Analyzed DNA damage repair pathways in colorectal cancer cells treated with fruquintinib and radiation.
• Utilized preclinical models to assess radiosensitivity changes with treatment.
• Fruquintinib significantly increased DNA damage in colorectal cancer cells after radiotherapy.
• The combination of fruquintinib and radiation showed higher tumor cell kill rates compared to radiation alone.
• Evidence supports potential clinical applications of fruquintinib with radiotherapy.