Decline of Visual Function and Risk of Legal Blindness With Age in RPGR-Associated Retinal Degeneration: A Multicenter Study. | Synapse
March 2, 2026
Decline of Visual Function and Risk of Legal Blindness With Age in RPGR-Associated Retinal Degeneration: A Multicenter Study.
Key Points
The study aims to investigate the decline of visual function and the risk of legal blindness in individuals with RPGR-associated retinal degeneration.
Conducted a multicenter study across different locations
Assessed changes in best-corrected visual acuity (BRVA) and Goldmann visual fields (GVF)
Analyzed data across multiple phenotypic groups within RPGR-RD
All phenotypic groups demonstrated a longitudinal loss of visual function
Rapid decline in GVF particularly noted in the RC phenotype, indicating a critical intervention window
Abstract
All phenotypic groups of RPGR-RD experienced longitudinal loss of BRVA and GVF. Rapid decline in GVF for the RC phenotype suggests that intervention may be most effective prior to this window.