Alteplase versus tenecteplase in acute ischemic stroke with large vessel occlusion: a systematic review and meta-analysis

Key Points

• Tenecteplase demonstrates superior outcomes in acute ischemic stroke cases compared to alteplase, suggesting a potential preference for its use.
• Key evidence shows a significant rate of reperfusion in patients treated with tenecteplase, highlighting its effectiveness in acute ischemic stroke.
• Systematic review and meta-analysis conducted on existing studies to evaluate the efficacy of alteplase versus tenecteplase in patients.
• Results support further exploration of tenecteplase for acute ischemic stroke management; more studies needed for validation.