Chlorpyrifos-induced autism and depression-like behaviors are ameliorated by trehalose: Integrating network pharmacology and toxicology analyses and animal experiments | Synapse
March 3, 2026
Chlorpyrifos-induced autism and depression-like behaviors are ameliorated by trehalose: Integrating network pharmacology and toxicology analyses and animal experiments
Key Points
Chlorpyrifos exposure leads to significant depression-like behaviors in animal models, indicating a strong association.
Animal experiments reveal that trehalose treatment significantly reduces these behaviors by altering related biomarkers.
Analysis integrates network pharmacology and toxicology to explore the underlying mechanisms and effects of trehalose.
These findings hint at new therapeutic strategies for managing chlorpyrifos-related behavioral issues in vulnerable populations.