Integrated bioinformatics and experimental validation identify FOXQ1, GRIN2D, and SCNN1B as novel biomarkers for distinguishing high-risk sessile serrated lesions from hyperplastic polyps

Key Points

• High-risk sessile serrated lesions can be distinguished from hyperplastic polyps using specific biomarkers.
• Key findings identified three novel biomarkers: FOXQ1, GRIN2D, and SCNN1B, enhancing diagnosis.
• Integrated bioinformatics and experimental validation methods were utilized in the biomarker identification process.
• These findings may enable improved diagnosis strategies, potentially leading to better patient outcomes.