S100-alarmins, antenatal corticosteroids and the risk of late-onset sepsis in preterm infants: A prospective cohort study

Key Points

• Late-onset sepsis risk varies based on the timing of antenatal corticosteroid administration in preterm infants.
• Administration of antenatal corticosteroids is associated with changes in S100A8/A9 levels influencing sepsis risk.
• Prospective cohort analysis across several neonatal units assesses the timing of corticosteroid treatment and its effects.
• Findings highlight the need for timely administration of corticosteroids to potentially reduce late-onset sepsis.