Circ₀001839 modulates the oncogenic MYCL rs1038259890 (p. G83S) mutation to promote BaP-induced malignant transformation in 16HBE cells

Key Points

• Malignant transformation occurs in 16HBE cells exposed to B[a]P, emphasizing the role of the MYCL mutation.
• The MYCL rs1038259890 mutation significantly promotes this transformation process.
• Analysis of 16HBE cells reveals interactions between circ_0001839 and the MYCL mutation.
• Understanding these mechanisms may lead to new insights in cancer therapies.