Improvement and engineering of methionine γ-lyase from Pseudomonas deceptionensis based on molecular dynamics simulation and adaptive analysis for anti-tumor applications

Key Points

• Methionine γ-lyase engineering demonstrates improved antitumor activity, suggesting potential therapeutic benefits.
• The study achieved a significant enhancement in enzyme efficacy through molecular dynamics simulation results.
• Utilizing adaptive analysis alongside simulation techniques facilitated optimized enzyme design for better performance.
• These findings highlight the need for broader testing across various cancer models to confirm efficacy.