Causal relationship between chronic kidney disease and senile cataract: a bidirectional two-sample Mendelian randomization study

Key Points

• Chronic kidney disease is causally related to the development of senile cataract, indicating a potential shared etiology.
• Data from two-sample Mendelian randomization shows that genetic factors contribute to both conditions, enhancing understanding of their link.
• Analysis using a bidirectional approach provides evidence for how chronic kidney disease may influence cataract formation over time.
• Highlighting this relationship suggests potential targets for early intervention and prevention strategies in at-risk populations.