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March 3, 2026
Open Access
African pygmy mouse iPSCs as a model for in vitro embryogenesis, interspecies chimerism, and blastocyst complementation
PG
Pjeter Gjonlleshaj
ETH Zurich
AL
Ajda Lenardič
ETH Zurich
MT
Monika Tarnowska-Sengül
ETH Zurich
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Key Points
Interspecies chimerism may be achieved using African pygmy mouse induced pluripotent stem cells (iPSCs) to enhance development.
The model demonstrates successful blastocyst complementation, showcasing a new frontier in embryonic research.
Assessment utilizing in vitro techniques provides insights into early embryogenesis through iPSCs.
Results suggest potential for broader applications in regenerative medicine and developmental biology.
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Gjonlleshaj et al. (Tue,) studied this question.
synapsesocial.com/papers/69a75b26c6e9836116a21f0b
https://doi.org/https://doi.org/10.1016/j.crmeth.2025.101293
African pygmy mouse iPSCs as a model for in vitro embryogenesis, interspecies chimerism, and blastocyst complementation | Synapse