Synthesis of an A/B- cis -Fused Cyclopenta b fluorene (6/5/6/5) Ring System for Embellicine A via the Eight-Membered Silylene-Tethered IMDA Reaction

Key Points

• The A/B-cis-fused tetracyclic compound was successfully synthesized with complete stereoselectivity, enabling further functionalization.
• Key reaction involved an intramolecular Diels-Alder reaction using a silylene tether to achieve significant conformational changes in the diene.
• This synthesis represents a novel approach to building complex polycyclic structures relevant in organic chemistry and medicinal applications.
• Functional group manipulations on the D-ring led to the successful formation of a tetracyclic fragment of embellicines, showcasing versatility in synthesis.