Silk fibroin-mediated poly(lactic acid)/poly(caprolactone) co-electrospun mats for pH-sensitive drug delivery systems

Key Points

• The co-electrospun mats exhibit significant pH-sensitive behavior, enhancing drug release profiles.
• Key metrics indicate a 40% increase in release at pH 7.4 compared to pH 5.5 in a buffered solution.
• Observational analysis of drug release dynamics and mat composition supports sustained release mechanisms.
• Implications include potential advancements in targeted drug delivery systems, necessitating further in vivo testing.